Neurobiology of Disease Targeting Astrocytes Ameliorates Neurologic Changes in a Mouse Model of Alzheimer’s Disease
نویسندگان
چکیده
Jennifer L. Furman,1 Diana M. Sama,4 John C. Gant,1 Tina L. Beckett,5 M. Paul Murphy,2,5 Adam D. Bachstetter,5 Linda J. Van Eldik,3,5 and Christopher M. Norris1,5 Departments of 1Molecular and Biomedical Pharmacology, 2Molecular and Cellular Biochemistry, and 3Anatomy and Neurobiology, 4Graduate Center for Gerontology, and 5Sanders-Brown Center on Aging, University of Kentucky College of Medicine, Lexington, Kentucky 40536
منابع مشابه
Cholinergic neuropathology in a mouse model of Alzheimer's disease
Transgenic mice over-expressing mutant human amyloid precursor protein (PDAPP mouse) develop several Alzheimer’s disease (AD)-like lesions including an age-related accumulation of amyloid-?-containing neuritic plaques. Although aged, heterozygous PDAPP mice also exhibit synaptic and glial cell changes, that is characteristic of AD pathology, no evidence of neurodegeneration has been observed. T...
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Astrocytes are the most abundant cell type in the brain and play a critical role in maintaining healthy nervous tissue. In Alzheimer's disease (AD) and most other neurodegenerative disorders, many astrocytes convert to a chronically "activated" phenotype characterized by morphologic and biochemical changes that appear to compromise protective properties and/or promote harmful neuroinflammatory ...
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